#WeekendRead! #EveryCellIsAnImmuneCell! #RememberMe! Xie, Zeng, Nagree, Jakobsen &co show @nature.com that upon TNF or LPS-driven inflammation, a subset of hematopoietic stem cells retains inflammatory epigenetic memory that can be transferred to immune cell progeny boosting all-cause mortality risk
Using xenograft inflammation–recovery models and single-cell multiomics, a haematopoietic stem cell population after inflammatory stress is identified.
