Fantastic work by Aakriti Jain @aakritijain.bsky.social in team
with Claire Goul and the Laboratory for Genome Research reveals the LASER pathway and its core component TFG as critical
for rapid ESCRT-dependent lysosomal membrane repair, pointing to a deep connection with neurodegeneration!
Roberto Zoncu Lab
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
