Assistant Professor at UT Southwestern Medical Center. aakritijainlab.com
Interested in #organelles, #metabolism, #membranes, #enzymes, #cancer, #neurodegeneration 🙂
Side interests include #cats, #beers, #pastries 🙃
Aakriti Jain
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If you will be at @ascbiology.bsky.social #CellBio2025 this coming week, let’s connect! I'm giving a talk on Tue Dec 9 at 10 AM in the “From Mechanisms to Therapeutic Insights in Neurodegeneration” session and a poster on Mon Dec 8 in the “Organelles – Endosome and Lysosomes” session. See you there!
Super excited to share that I will be starting my lab at UT Southwestern Medical Center this January!
We will explore how lysosomes drive cellular metabolism and signaling to better understand disease to develop new therapies for cancer and neurodegeneration. More info here: aakritijainlab.com
I am looking for curious and creative scientists at all levels (technicians, postdocs, graduate students, …) to join the team. Please spread the word and reach out if you are interested!
Online Now: Lysosomes as hubs of metabolic sensing and cellular homeostasis Online now:
Had an incredible time at the @embo.org meeting on organelles in Hyderabad, India! So much great science (and food!) #emboccmb25
Excited to share our work @nature.com! Postdoc @mariopalma.bsky.social, with major contributions from @retickerflynn.bsky.social and collaborators, discovered melanoma cells in lymph nodes gain a targetable FSP1 dependency that limits progression. #TeamFSP1
www.nature.com/articles/s41...
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
The ESCRT machinery mediates repair of damaged lysosomal membranes. But how does it recognise damage? Authors @nature report LASER, a fast-forming protein assembly that detects Ca2+-leakage from sites of lysosomal injury and recruits ESCRTs there.
shorturl.at/T9zM6
Aakriti Jain
Aakriti Jain
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
shorturl.at
Ubellacker Lab
SFB Targeted Protein Degradation
Sadaf Shadan
DeBerardinis Lab at UT Southwestern Medical Center
Jain et al. review how lysosomes act as signaling hubs that couple nutrient export to sensing pathways controlling growth, stress responses, and organelle crosstalk. They highlight immune- and neuron-specific lysosomal programs that integrate metabolic status and organelle health to shape tissue physiology.dlvr.it
