"It's less like pressing a button for an answer and more like mentoring a junior colleague—asking the right questions, pushing back on shallow reasoning, and nudging the system toward sharper insights."
Our new study reveals how bacterial toxins are physically captured through a sequential, concentration-dependent assembly mechanism before secretion via the T6SS.
Fantastic collaboration with @fillouxlab.bsky.social. Congrats Patricia & Ambre for leading this work.
Paper here: shorturl.at/O31Vn
Google's AI co-scientist is proving itself more than a novelty. In two biology studies, it generated exciting ideas that could have taken years of lab work to uncover.
📢 We are recruiting!
I’m looking for a Research Associate in Structural Biology to join my lab at Imperial College London to study horizontal gene transfer using cryo-EM, biochemistry and microbiology.
Please share with interested candidates!
Apply: shorturl.at/gmJGS
🚨 PhD Opportunity in my lab🚨
Harnessing Phage Satellites for Next-Generation Biological Crop Protection
🗓 Deadline: 12 Jan
🔗 Apply: tinyurl.com/425x8ahj
🔗 Project : tinyurl.com/22uanm86
Interested in Structural Microbiology, Phage Biology & SynBio - Apply Now!
🚨 PhD Opportunity in my lab🚨
Harnessing Phage Satellites for Next-Generation Biological Crop Protection
🗓 Deadline: 12 Jan
🔗 Apply: tinyurl.com/425x8ahj
🔗 Project : tinyurl.com/22uanm86
Interested in Structural Microbiology, Phage Biology & SynBio - Apply Now!
Please RT:📢We are hiring a Post-Doc in Structural Biology to join our multidisciplinary team.
Project: study molecular mechanisms of horizontal gene transfer using cryo-EM and integrative structural biology.
Apply: shorturl.at/ecrVL
#StructuralBiology #CryoEM #Postdoc
This paper started as an idea @albertomarina.bsky.social had many years ago… which of course means he was right all along 😄. Some of us just needed a few years (and a lot of experiments) to catch up.
Grateful (and slightly humbled) to be part of this. Thanks Alberto!
www.cell.com/cell/fulltex...
Structural analysis reveals that the type VI secretion system effector cargo is enclosed within hexameric Hcp3 rings that form sequentially to enable effector loading and delivery by the Pseudomonas aeruginosa H3-type VI secretion system.
New paper just out from #OurImperial @tcostalab.bsky.social
The assembly of a hybrid type IV secretion system by a Crohn’s disease-associated Escherichia coli strain.
www.nature.com/articles/s41...
Imperial researchers have discovered how ‘pirate phages’ hijack other viruses to break into bacteria, sharing new genetic material for dangerous traits.
This discovery that could be harnessed to tackle #AMR
Read more ⬇️
www.imperial.ac.uk/news/268213/...
IEEE Spectrum
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
The Grantham Institute - Climate Change and the Environment invites PhD applications that support projects in some of our priority research areas. In...
The Grantham Institute - Climate Change and the Environment invites PhD applications that support projects in some of our priority research areas. In...
tinyurl.com
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
Gallego-del-Sol et al. show that arbitrium-coding phages can sense non-cognate peptide
signals from other phages to regulate lysis-lysogeny decisions. This crosstalk affects
lysis-lysogeny outcomes of...
www.cell.com
Tiago Costa
Tiago Costa
Tiago Costa
Adherent-invasive strains of E. coli are commonly isolated from patients with Crohn’s disease. Here, the authors show that an AIEC harbours a hybrid Type IV secretion system (T4SS) that mediates pilin...
Out Now! Molecular basis of type VI secretion system effector loading #MicroSky
Imperial Science
Imperial Life Sciences
Nature Microbiology, Published online: 27 May 2026; doi:10.1038/s41564-026-02363-xStructural analysis reveals that the type VI secretion system effector cargo is enclosed within hexameric Hcp3 rings that form sequentially to enable effector loading and delivery by the Pseudomonas aeruginosa H3-type VI secretion system.
