Using EBV-activated effector T cells as a benchmark, Maccari, Geltink, Rensing-Ehl et al. show that FAS-controlled #Tcells display comparably heightened glycolysis, but a metabolic program uncoupled from T-BET expression and IFNγ production. rupress.org/jhi/article/...
#InbornErrorsofImmunity
Primary atopic disorders: Monogenic insights into immunity. Bhavi Modi, Stuart Turvey @turveylab.bsky.social et al. review how primary atopic disorders, a group of monogenic #InbornErrorsOfImmunity, reveal fundamental mechanisms regulating allergic #inflammation.
rupress.org/jhi/article/...
#Atopy
Functional characterization of Griscelli syndrome type 2 sine albinism in Japanese patients. New study from Tatsuhiko Tanaka, Akira Sugawara, Ko Kudo (Hirosaki University), Mitsunori Fukuda (Tohoku University) and colleagues:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
📢 #FOCIS2026 attendees: Join our Executive Editor Natalie Cain (@nataliecain.bsky.social) TODAY for a "Meet the Editor" session at 11:45 am - 1:00 pm!
💡 Gain insights into the peer review process, and learn how to prepare a manuscript for publication and respond to reviewers’ comments!
Journal of Human Immunity
Journal of Human Immunity
Journal of Human Immunity
Journal of Experimental Medicine
Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis. From Adrian Gervais, Aurélie Cobat, @casanovalab.bsky.social, Emmanuelle Jouanguy et al: rupress.org/jem/article/...
📘 From our Clinical #Immunology Collection 👉 rupress.org/jem/collecti...
#FOCIS2026
FAS-controlled #Tcells drive #lymphoproliferation through #glycolysis without effector differentiation. New study from Maria Elena Maccari, Ramon I. Klein Geltink @bcchresearch.bsky.social, Anne Rensing-Ehl @uni-freiburg.de and colleagues:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity
Ribosomal RNA processing impairments in a B cell immunodeficient patient with WDR75 variants. New study from Nidia Moreno-Corona, Sven Kracker @institutimagine.bsky.social and colleagues:
rupress.org/jhi/article/...
#RareDisease #ClinicalPhenotypes #InbornErrorsOfImmunity
Adult-onset STING-associated vasculopathy. New study from Thomas R. Riley, Jonathan J. Kotzin, Amanda V. Finck, Jonathan J. Miner and colleagues (UPenn Perelman School of Medicine):
rupress.org/jhi/article/...
#Autoimmunity #ClinicalPhenotypes #ImmunologicalPhenotypes #InbornErrorsOfImmunity
HERE IS WHY:
Autoantibodies against Cytokines — From Infection to Inflammation | New England Journal of Medicine www.nejm.org/doi/10.1056/...
THIS IS THE BEST PAPER OF 2026 SO FAR, A MONUMENTAL BREAKTHROUGH, A REVOLUTION IN THE FIELD OF INFLAMMATORY CONDITIONS:
Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | New England Journal of Medicine www.nejm.org/doi/10.1056/...
Journal of Experimental Medicine
Journal of Human Immunity
Journal of Human Immunity
Journal of Human Immunity
The authors describe the scientific foundations of a study implicating autoantibodies against interleukin-10 in persons with inflammatory bowel disease.
Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic
defects of interleukin-10 signaling in children and may be associated with inflammatory
bowel disease (IBD)...
