Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...
The Cordero Vásquez Lab is starting the year on a high wheel (see below) with our latest work on the C. elegans PIEZO channel: “Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade”: www.sciencedirect.com/science/arti...
1/5
iGluR excitation - not just in dendrites!
"Excitatory synapses onto axonic spines jump-start action potentials and route information flow"
rdcu.be/fjy9p
#iGluRs #neuroscience
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
🚨🧠🔬 Dopamine was discovered over a century ago, and has long been thought to only signal through metabotropic means. In our new preprint, we provide evidence that dopamine can directly signal through the "orphan" GluD ionotropic receptors.
More to come!
#iGluRs #neuroscience #dopamine #cryoEM
Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!
Video
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
PIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t…
Nature Neuroscience - The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These...
rdcu.be
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...
My OpEd piece in US News & World Report, about not wanting my life to be book-ended by two fascist regimes and about the state of higher education in this country,
www.usnews.com/opinion/arti...
has now been republished in German translation by JOSHA:
josha-journal.org/en/categorie...
What a breakthrough! Such a puzzle for 30 years, this is real progress!
I wonder how general this mechanism of repression is for other systems where highly-selective expression is needed.
www.biorxiv.org/content/10.6...
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
Calcium and magnesium in the pore of NMDA receptors!
Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O.
Very stimulating work! Congrats @lab-furukawa.bsky.social
#iglurs
Ardem Patapoutian
Joachim Frank
Andrew Plested
Andrew Plested
BREAKING: The Nobel Prize in Chemistry has been awarded to Susumu Kitagawa, Richard Robson and Omar M. Yaghi “for the development of metal-organic frameworks”
Stay tuned for more.
#NobelPrize
On the mechanism of calcium permeability and magnesium block in NMDA receptors - a central molecular paradigm in neuroplasticity https://www.biorxiv.org/content/10.1101/2025.11.06.686637v1
