Happy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7)
www.biorxiv.org/content/10.6...
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
My OpEd piece in US News & World Report, about not wanting my life to be book-ended by two fascist regimes and about the state of higher education in this country,
www.usnews.com/opinion/arti...
has now been republished in German translation by JOSHA:
josha-journal.org/en/categorie...
Video
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...www.jneurosci.org
The Cordero Vásquez Lab is starting the year on a high wheel (see below) with our latest work on the C. elegans PIEZO channel: “Structures of invertebrate PEZO-1 isoforms with a compact architecture and a dispensable pore-distal N-terminal blade”: www.sciencedirect.com/science/arti...
1/5
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
🚨🧠🔬 Dopamine was discovered over a century ago, and has long been thought to only signal through metabotropic means. In our new preprint, we provide evidence that dopamine can directly signal through the "orphan" GluD ionotropic receptors.
More to come!
#iGluRs #neuroscience #dopamine #cryoEM
Congrats to the winners! Its notable that Omar Yaghi was a refugee. Refugees and immigrants once again making American science great!
PIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define t…
www.sciencedirect.com
iGluR excitation - not just in dendrites!
"Excitatory synapses onto axonic spines jump-start action potentials and route information flow"
rdcu.be/fjy9p
#iGluRs #neuroscience
Nature Neuroscience - The axon initial segment was known to receive GABAergic synaptic inputs. Yang et al. show that it can be excited directly via specialized ‘axonic spines’. These...
What a breakthrough! Such a puzzle for 30 years, this is real progress!
I wonder how general this mechanism of repression is for other systems where highly-selective expression is needed.
www.biorxiv.org/content/10.6...
Ed Twomey
Ed Twomey
The ability to discriminate thousands of odors in our environment requires each olfactory neuron to express a single olfactory receptor from hundreds of available genes. The biochemical mechanism enfo...
