🚨🧠🔬 Dopamine was discovered over a century ago, and has long been thought to only signal through metabotropic means. In our new preprint, we provide evidence that dopamine can directly signal through the "orphan" GluD ionotropic receptors.
More to come!
#iGluRs #neuroscience #dopamine #cryoEM
Ed Twomey
GluDs are ionotropic dopamine receptors tuned by G-proteins https://www.biorxiv.org/content/10.64898/2026.05.10.723887v1
