Group leader at Max Perutz Labs interested in protein quality control
Elif Karagöz
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BacPROTACs outperform inhibitors in Mycobacterium tuberculosis https://www.biorxiv.org/content/10.64898/2026.06.12.731830v1
a small attempt to capture this enormous loss and what Greg meant and means to so many.
www.cell.com/cell/fulltex...
www.nature.com/articles/s41...
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2
go.nature.com/4v7ZeTt
Single molecule studies from Arda Mizrak in the Farese/Walther @msk & Harper Labs @harvardcellbio.bsky.social shows how lipid droplet proteins track through ER networks to ultimately partition into nanodomains on droplets, dependent upon Trp-containing hairpin motifs www.nature.com/articles/s41...
The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox:
www.nature.com/articles/s41...
