Group leader at Max Perutz Labs interested in protein quality control
Elif Karagöz
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www.nature.com/articles/s41...
Finally out in @Cellcellpress!
Proteins with long IDRs are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
www.cell.com/cell/fulltex...
Nature research paper: Substrate selectivity of the human RNA m5C methyltransferase NSUN2
go.nature.com/4v7ZeTt
Single molecule studies from Arda Mizrak in the Farese/Walther @msk & Harper Labs @harvardcellbio.bsky.social shows how lipid droplet proteins track through ER networks to ultimately partition into nanodomains on droplets, dependent upon Trp-containing hairpin motifs www.nature.com/articles/s41...
The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox:
www.nature.com/articles/s41...
New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion.
Read on 🧵👇 and check out our preprint for more details!
tinyurl.com/34cm4xat
Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...
So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...
📣 Registration is open for the 20th Microsymposium on RNA Biology!
Join in at the Vienna BioCenter for three days of cutting-edge science, discussion & networking.
📅 17-19 June 2026
🧬 Poster abstract deadline: 19 May
Info & registration: www.oeaw.ac.at/imba/seminar...
Structures of the AGO maturation complex reveal how chaperones and an RNA duplex drive assembly of the RNA-induced silencing complex.
www.nature.com
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically
disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis
of fully active proteins.
NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based on specific sequence patterns and structural features.
Mizrak et al. use single-molecule tracking to dissect mechanisms of protein targeting to lipid droplets. They show that nanodomain-based confinement drives selective protein accumulation on lipid drop...
www.nature.com
Signal peptides are highly variable, yet the signal peptidase complex processes them with remarkable specificity. Here, authors combine cryo-EM, molecular dynamics simulations and modeling to reveal a...
ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.
How do sperm and egg fuse? Surprisingly, we still don’t fully know…
Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together.
We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion.
tinyurl.com/34cm4xat
Read on! 🧵👇
