New pre-print from the lab! Murepavedin is a Pseudomonas-specific antibiotic, but it disrupts the outer membranes of a wide range of different Gram-negatives. www.biorxiv.org/content/10.6...
Excited to share our new preprint on a question that has puzzled us for a long time: How can the bacterial nano-weapon, type VI secretion system (T6SS), load and deliver so many antibacterial toxins that are completely different in structure and function?
www.biorxiv.org/content/10.6...
EMBO Symposium alert:
Save the date: 9–12 March 2027
Join us in scenic Heidelberg for this unique meeting, covering everything about drug resistance and tolerance.
Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer www.embl.org/about/info/c...
Our new study reveals how bacterial toxins are physically captured through a sequential, concentration-dependent assembly mechanism before secretion via the T6SS.
Fantastic collaboration with @fillouxlab.bsky.social. Congrats Patricia & Ambre for leading this work.
Paper here: shorturl.at/O31Vn
How do dangerous bacteria arm themselves before attack? Scientists from NTU-SCELSE and Imperial College London uncovered a previously unknown mechanism showing how bacteria load toxins into a microscopic weapon system before firing. Nature Microbiology-> rdcu.be/fk0Bq @fillouxlab.bsky.social
@vanipande.bsky.social presenting her work at #ASMicrobe today....
Check out her recent preprint about a spontaneously inserting integral membrane protein that localized by recognizing a lipid cue
Archaea the hornets of the microbial world. Discuss.
www.biorxiv.org/content/10.6...
TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
See-Yeun Ting 陳詩允
A new study from the @rocklabtb.bsky.social in @natmicrobiol.nature.com finds that one of the most common drug resistance mutations in #tuberculosis creates subtle metabolic weaknesses that could be exploited with future combination therapies.
🔗: https://bit.ly/3RG6wj2
@felixrl.bsky.social presenting his work at #ASMicrobe today. His preprint follows up on his recent work on orthogonal cell division in S. aureus and reports that PcdA, the division septum placement factor, is required for forming staphylococcal abscess colonies.
Bacterial transmembrane proteins usually localize inside the cell by "finding" a pre-localized protein, but how did the 1st protein get there? @vanipande.bsky.social found a protein in #B.subtilis that localizes by recognizing a *lipid* localization cue. #Microsky
www.biorxiv.org/content/10.6...
Tiago Costa
SCELSE - a biofilm & microbiome research centre in NTU & NUS
Luiz Pedro Carvalho, PhD
Andy Edwards
The Rockefeller University
Kumaran Ramamurthi
Kumaran Ramamurthi
Kumaran Ramamurthi
Tobias Warnecke
Murepavadin is a Pseudomonas-specific antibiotic that targets LPS transport protein LptD. However, whilst the mode of action of murepavadin is well defined, the mechanism by which the drug gains acces...
Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...
Bacterial transmembrane proteins usually localize inside the cell by "finding" a pre-localized protein, but how did the 1st protein get there? @vanipande.bsky.social found a protein in #B.subtilis that localizes by recognizing a *lipid* localization cue. #Microsky
www.biorxiv.org/content/10.6...
www.biorxiv.org
@felixrl.bsky.social reported that PcdA mediates orthogonal cell division in #Staphylococcus aureus: www.nature.com/articles/s41....
But what’s the point? Well, forming staphylococcal abscess communities to evade host immune responses requires this mode of division:
www.biorxiv.org/cgi/content/...
Kumaran Ramamurthi
Kumaran Ramamurthi
Structural analysis reveals that the type VI secretion system effector cargo is enclosed within hexameric Hcp3 rings that form sequentially to enable effector loading and delivery by the Pseudomonas aeruginosa H3-type VI secretion system.
PcdA interacts with DivIVA and FtsZ, promoting Z-ring formation and division plane selection in Staphylococcus aureus, which increases virulence in mice and reduces sensitivity to cell-wall-targeting ...
