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#Neuroscience #Neurology #Neurophysiology #ParkinsonsDisease #DeepBrainStimulation #DBS #STN #LFP #Neurotechnology #Aperiodic #CodeSharing #Reproducibility #SignalProcessing

Our new preprint on promises and caveats of the extraction of M/EEG activity from ROIs is out (see more details in the reposted thread): www.biorxiv.org/content/10.6... Huge thanks to @studenova.bsky.social, Ruben Eguinoa, Guido Nolte, @sparsity.bsky.social, Arno Villringer, and Vadim Nikulin!

#Neuroscience #Neurology #Neurophysiology #ParkinsonsDisease #DeepBrainStimulation #DBS #STN #LFP #NeuralEngineering #Neurotechnology #Neuromodulation #Aperiodic

6mo

𝐎𝐮𝐫 𝐚𝐩𝐩𝐫𝐨𝐚𝐜𝐡: We used aperiodic broadband power and mid gamma as LFP proxies for subthalamic firing. 𝐑𝐞𝐬𝐮𝐥𝐭: Aperiodic broadband power correlated with motor symptoms both OFF and ON medication. The same was true for mid gamma.

PS: This finding isn’t in the abstract and is easy to miss, so consider sharing it with colleagues working on automated DBS programming.

Increased firing could so far only be confirmed 𝗱𝘂𝗿𝗶𝗻𝗴 surgery using microelectrodes, in the absence of Levodopa medication. Due to these technical constraints, most human studies have focused on beta and largely ignored the firing. We know Levodopa reduces beta – but how does it affect firing?

Parkinson’s disease involves two major abnormalities in subthalamic nucleus activity: 1️⃣ Excessive beta (13–30 Hz) rhythms 2️⃣ Increased neuronal firing Beta can be measured 𝗮𝗳𝘁𝗲𝗿 surgery using deep brain stimulation electrodes.

1️⃣ Don’t normalize power spectra. Absolute beta power (µV²/Hz) performs better than relative “% of total power.” 2️⃣ Remove the aperiodic component using specparam. Isolating the periodic beta peaks improves the SNR. The high beta maps shrink toward the therapeutic sweet spot (blue sphere in video).

𝐈𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: Mid gamma power is a promising medication-independent biomarker for adaptive deep brain stimulation—and it could be implemented in existing hardware (e.g., Medtronic Percept™ PC). Open-access paper: doi.org/10.1016/j.eb...

6mo

Moritz Gerster

Nikolai Kapralov

6mo

Moritz Gerster

6mo

𝐈𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: Absolute periodic high beta power could be used for automatic deep brain stimulation programming. Horn et al. 2017: doi.org/10.1002/hbm.... Darcy et al. 2022: doi.org/10.1016/j.ex... 𝐆𝐞𝐫𝐬𝐭𝐞𝐫 𝐞𝐭 𝐚𝐥. 𝟐𝟎𝟐𝟓: doi.org/10.1016/j.eb...

Moritz Gerster