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Moritz Gerster
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𝐎𝐮𝐫 𝐚𝐩𝐩𝐫𝐨𝐚𝐜𝐡:
We used aperiodic broadband power and mid gamma as LFP proxies for subthalamic firing.
𝐑𝐞𝐬𝐮𝐥𝐭:
Aperiodic broadband power correlated with motor symptoms both OFF and ON medication. The same was true for mid gamma.
𝐈𝐦𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧:
Mid gamma power is a promising medication-independent biomarker for adaptive deep brain stimulation—and it could be implemented in existing hardware (e.g., Medtronic Percept™ PC).
Open-access paper: doi.org/10.1016/j.eb...
Increased firing could so far only be confirmed 𝗱𝘂𝗿𝗶𝗻𝗴 surgery using microelectrodes, in the absence of Levodopa medication.
Due to these technical constraints, most human studies have focused on beta and largely ignored the firing.
We know Levodopa reduces beta – but how does it affect firing?
