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Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
As promised: We have an open 2-year postdoc position in my lab at HHU Düsseldorf, starting September 2026. Come join us and help pioneering structural biology of fungal GPCRs! More about the lab: altegoerlab.de Apply here: karriere.hhu.de/index.php?ac... Please share with interested candidates!
Please RT: Registration is ongoing for our International Symposium "Microbial Networking - from organelles to cross-kingdom communities" organized as highlight of the first funding period of CRC 1535 @mibinet.bsky.social www.sfb1535.hhu.de/internationa... @dfg.de, @hhu.de, @fz-juelich.de
14h
1d
7d
Now out in @pnas.org 🥳 "DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity" --> bad timing can kill you, even as a virus. www.pnas.org/doi/10.1073/... @spp2330.bsky.social, @mibinet.bsky.social, @dfg.de
6d
Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe. 📄 www.nature.com/articles/s41... 💾 folddisco.foldseek.com​​​​​​​​​​​​​​​​ 🌐 https://search.foldseek.com/folddisco
Effector recognition by molecular mimicry of its target by an NLR - enabling multiple disease resistance specificities to be generated- first seen on @biorxiv-plants.bsky.social - great work led by @dianagdlc.bsky.social and Matt Moscou www.science.org/doi/10.1126/...
🦠 How did our cells originate? A study by #IRBBarcelona & @bsc-cns.bsky.social by @gabaldonlab.bsky.social, suggests cellular complexity arose through long-term microbial alliances rather than a single evolutionary event. @nature.com ➡️ https://shorturl.at/kCij7 📌 DOI: 10.1038/s41586-026-10639-9
karriere.hhu.de
Postdoc (m/f/d) structural biology of fungal G-Protein coupled receptors
Everything you wanted to know about the protein chemistry behind how amino-acid changes affect the cellular abundance of proteins from @tkschulze.bsky.social Effects of residue substitutions on the cellular abundance of proteins doi.org/10.7554/eLif...
4d
5d
Toni Gabaldón
Altegoerlab
Julia Frunzke
14h
11d
‼️Job alert📢🚨 We are recruiting a Junior Group Leader (f) in Protein Science at Martin Luther University Halle-Wittenberg, jointly hosted by the Institute of Biochemistry and Biotechnology and our Collaborative Research Centre CRC 1664 "Plant Proteoform Diversity – SNP2Prot."
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
PNAS
Julia Frunzke
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
www.science.org
Molecular mimicry of a pathogen virulence target by a plant immune receptor
Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis doi.org/10.7554/eLif... - The final version of a long story! Biochemical analysis of MinD in vitro and in vivo (with SMLM). Credit goes to @drhelgon.bsky.social!
2d
We just received funding for a 2yr postdoc position on cryoEM of fungal gpcrs. Official call will open soon. Contact me if you‘re interested!
Martin Steinegger 🇺🇦
Nick Talbot
IRB Barcelona
2d
Folddisco enables protein structural motif search in million scale databases.
www.nature.com
Structural motif search across the protein universe with Folddisco - Nature Biotechnology
1mo
Kresten Lindorff-Larsen
Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min ...
doi.org
Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis
Altegoerlab
Der Biologe Dr. Florian Altegoer vom Institut für Mikrobiologie der Heinrich-Heine-Universität Düsseldorf (HHU) erhält einen mit 210.000 Euro dotierten „Exploration Grant“ der Boehringer Ingelheim Stiftung (BIS).
1mo
Happy to share our recent preprint: "DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity" www.biorxiv.org/content/10.6... @spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social
4mo
Heinrich-Heine-Universität Düsseldorf
Thorsten Langner
Julia Frunzke
Marc Bramkamp
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬 📄 www.biorxiv.org/content/10.1... 🌐 search.foldseek.com/folddisco
11mo
Video
Martin Steinegger 🇺🇦