Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe.
📄 www.nature.com/articles/s41...
💾 folddisco.foldseek.com
🌐 https://search.foldseek.com/folddisco
I wrote about AI in academia. "PhD-level thinking", LLM bias, grunt work, alignment, AGI, data center water use, AI politics -- something for everyone.
PhD-level thinking, LLM bias, alignment, AGI, data centers, and AI politics
Very cool! 😎⤵️ Folddisco 🪩 a motif search algorithm that supports querying both short motif queries (Fig. 1d) and long, discontinuous segments (Fig. 1e) in seconds against 53 million structures 🥳🥳
www.nature.com/articles/s41...
Find more details here: bsky.app/profile/hbkg...
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
Why AI-assisted research might have a lower impact that some estimate? I tried to look back at the rise of the internet and its impact on scientific research as a comparison point. I should stop spending time on this but condensing this info also helps me think www.evocellnet.com/2026/06/look...
There is a lot of debate and some hyperbole around the impact of AI-assisted scientific research. When considering the future impact of gene...
Does your designed active site already exist in nature? Is an uncharacterized protein hiding a catalytic site or a pocket? Folddisco answers both, searching millions of structures for a 3D motif in seconds.
@natbiotech.nature.com 🧬
📄 www.nature.com/articles/s41...
🧵1/7👇
Does your designed active site already exist in nature? Is an uncharacterized protein hiding a catalytic site or a pocket? Folddisco answers both, searching millions of structures for a 3D motif in seconds.
@natbiotech.nature.com 🧬
📄 www.nature.com/articles/s41...
🧵1/7👇
Folddisco enables protein structural motif search in million scale databases.
www.nature.com
Folddisco enables protein structural motif search in million scale databases.
