Membrane binding controls the ATPase cycle and localization of MinD in Bacillus subtilis doi.org/10.7554/eLif... - The final version of a long story! Biochemical analysis of MinD in vitro and in vivo (with SMLM). Credit goes to @drhelgon.bsky.social!
Folddisco is now published @natbiotech.nature.com. It’s a fast motif search for similar 3D DISCOntinuous residues like catalytic sites or zinc fingers across the entire protein universe.
📄 www.nature.com/articles/s41...
💾 folddisco.foldseek.com
🌐 https://search.foldseek.com/folddisco
As promised: We have an open 2-year postdoc position in my lab at HHU Düsseldorf, starting September 2026.
Come join us and help pioneering structural biology of fungal GPCRs!
More about the lab: altegoerlab.de
Apply here: karriere.hhu.de/index.php?ac...
Please share with interested candidates!
Dynamic relocalization of MinD in Bacillus subtilis arises from membrane binding of monomers and dimers with membrane-triggered ATP hydrolysis, suggesting MinE-like activators are unnecessary for Min ...
Folddisco finds similar (dis)continuous 3D motifs in large protein structure databases. Its efficient index enables fast uncharacterized active site annotation, protein conformational state analysis and PPI interface comparison. 1/9🧶🧬
📄 www.biorxiv.org/content/10.1...
🌐 search.foldseek.com/folddisco
Effector recognition by molecular mimicry of its target by an NLR - enabling multiple disease resistance specificities to be generated- first seen on @biorxiv-plants.bsky.social - great work led by @dianagdlc.bsky.social and Matt Moscou
www.science.org/doi/10.1126/...
Martin Steinegger 🇺🇦
Plants and animals respond to pathogen attack by mounting innate immune responses that require intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. These immune receptors detect pathog...
‼️Job alert📢🚨
We are recruiting a Junior Group Leader (f) in Protein Science at Martin Luther University Halle-Wittenberg, jointly hosted by the Institute of Biochemistry and Biotechnology and our Collaborative Research Centre CRC 1664 "Plant Proteoform Diversity – SNP2Prot."
Nick Talbot
Everything you wanted to know about the protein chemistry behind how amino-acid changes affect the cellular abundance of proteins from @tkschulze.bsky.social
Effects of residue substitutions on the cellular abundance of proteins
doi.org/10.7554/eLif...
Now out in @pnas.org 🥳
"DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity"
--> bad timing can kill you, even as a virus.
www.pnas.org/doi/10.1073/...
@spp2330.bsky.social, @mibinet.bsky.social, @dfg.de
