What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky ๐งช
โGood things take timeโ
Allogeneic Treg do not prevent their own rejection in immunocompetent hosts - HLA matching or HLA editing required for optional function!
A beautiful collaboration with Fadi Issa & Joanna Hesterโs team @ox.ac.uk. @dlwagnerlabs.bsky.social
Tregs in the skin reduce the activation of sensory neurons by producing enkephalin. This inhibits secondary inflammatory changes mediated by the neurons. (in ๐ญ)
๐งช โ
Mendoza et al 2025 in Science Immunology
www.science.org/doi/full/10....
Adapting the 10x workflow to detect EBV reads, Younis et al show that EBV-transcribing B cells are increased in SLE patients, especially among CD27+CD21low B cells. They have autoreactive BCRs and are more poised for antigen-presentation.
2025 Sci Transl Med ๐งช โ
www.science.org/doi/10.1126/...
Ubiquitinylation is more complex than just a signal for proteasomal degradation: Linear ubiquitinylation of Methionine-1 is important for NFkB signalling.
LOF of the Deubiquitinylase OTULIN leads to an autoinflammatory disease with a TNF positive feedback loop.
๐งช โ
1/2
CRISPR screening factors influencing Th1 vs Th2 differentiation, RAMP3 which forms part of a CGRP receptor is a positive regulator of Th1 differention. CGRP acts by increasing intracellular cAMP and ultimately ATF3 activity it induces STAT1 and thereby Th1 differentiation. in ๐ญ
๐งช โ 1/2
immunoboys
Dimitrios L. Wagner
Damgaard et al โ 2016 โ The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity in @cellpress.bsky.social
doi.org/10.1016/j.ce...
