🚨 New in JMCC! Multi-omics approaches reveal that impaired VSMC TGF-β signaling drives mitochondrial dysfunction, contributing to the pathogenesis of thoracic aortic aneurysm and dissection.
www.jmcc-online.com/article/S002...
🚨 New in JMCC: Zhang et al. identify LARP7 as a regulator of cardiomyocyte proliferation and cardiac regeneration. LARP7 promotes G2/M transition and, with CDK4/CCND1, improves heart repair after injury ❤️🩹
www.jmcc-online.com/article/S002...
🚨 New in JMCC! Ventricular arrythmias drive sudden cardiac death after MI. Zhou et al. show that reducing KCNQ2 in stellate ganglion neurons worsens these arrythmias.
www.jmcc-online.com/article/S002...
🚨 New in JMCC! Paired human LV and RV biopsy metabolomics reveal that ischemia-reperfusion causes greater metabolic depletion in the LV, especially during CABG, highlighting ventricle-specific vulnerabilities in cardiac surgery.
www.jmcc-online.com/article/S002...
🆕 in JMCC Special Issue on The Diabetic Heart: Kanki and Young review the role of mineralocorticoid receptor signaling in diabetic cardiomyopathy and its potential as a therapeutic target to reduce cardiovascular risk 🫀 💪🏼
www.jmcc-online.com/article/S002...
🆕 in JMCC: PERK is a key regulator of the unfolded protein response, but its activation mechanisms remain unclear. Georgoula et al. identify stable PERK assembly states that persist during ER stress, suggesting new modes of regulation 👏🏼
www.jmcc-online.com/article/S002...
🚨 New in JMCC! The GWAS-identified CAD risk gene and transcription factor PRDM16 is a key regulator of VSMC homeostasis, promoting proliferation and neointima formation by repressing Tgfb2 expression.
www.jmcc-online.com/article/S002...
🚨 New in JMCC: Zheng et al. identify DPP4 as a key regulator of endothelial ferroptosis in atherosclerosis. DPP4 promotes ferritinophagy, endothelial dysfunction, and plaque progression, highlighting a potential therapeutic target 🎯
www.jmcc-online.com/article/S002...
🚨 New in JMCC! CDNF’s C-domain drives potent cardioprotection via PI3K/Akt signaling and mediates ER stress–dependent KDEL receptor binding, while the N-domain is essential for CDNF internalization.
www.jmcc-online.com/article/S002...
Effective myocardial protection during cardiac surgery is essential, yet the differential metabolic stress of the left (LV) and right ventricles (RV) to ischemia–reperfusion remains poorly…
www.jmcc-online.com
Ventricular arrhythmias (VAs) are a leading cause of sudden cardiac death (SCD) following myocardial infarction (MI), with cardiac sympathetic hyperexcitability serving as a critical trigger. While…
Mitochondrial dysregulation promotes vascular destabilization through modulation of the phenotypic plasticity of vascular smooth muscle cells (VSMCs) in thoracic aortic aneurysms and dissections…
Vascular smooth muscle cells (VSMCs) are the primary contractile component of blood vessels and can undergo phenotypic switching from a contractile to a synthetic phenotype in vascular diseases such…
Cerebral dopamine neurotrophic factor (CDNF) has emerged as a key cytoprotective molecule, with well-documented neuroprotective effects in Parkinson's disease models and, more recently, demonstrated…
🆕 in JMCC: Bacchini et al. show that aging and cardiomyopathy jointly reshape unfolded protein response pathways, highlighting defective proteostasis as a key contributor to myocardial dysfunction and heart failure 👴🏼👵🏼🫀
www.jmcc-online.com/article/S002...
