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🚨 New in JMCC! CDNF’s C-domain drives potent cardioprotection via PI3K/Akt signaling and mediates ER stress–dependent KDEL receptor binding, while the N-domain is essential for CDNF internalization. www.jmcc-online.com/article/S002...
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Cerebral dopamine neurotrophic factor (CDNF) has emerged as a key cytoprotective molecule, with well-documented neuroprotective effects in Parkinson's disease models and, more recently, demonstrated…
www.jmcc-online.com
The C-domain of the cerebral dopamine neurotrophic factor (CDNF) is responsible for its cardioprotective activity by binding to the KDEL receptor relocated to the plasma membrane under endoplasmic reticulum stress conditions
Journal of Molecular and Cellular Cardiology