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A stimuli-responsive ex vivo model of osteoarthritis demonstrates TLR4-mediated cartilage degradation and a Rapamycin-induced fast matrix recovery https://www.biorxiv.org/content/10.64898/2026.06.09.731049v1

This is an interesting one.

"metabolic-cytoskeletal axis that determines cellular polarity or a/symmetry prior to the onset of cell division. This suggests that polarity loss during cytokine-driven culture is a regulated feature of early cellular adaptation, rather than an inevitable consequence of cell-cycle entry"

“Interestingly, we examined O-GlcNAcylation and hyaluronan production, both of which draw from the same UDP-GlcNAc pool as N-linked glycosylation, and observed a mild decrease in the brain for both pathways”