“Interestingly, we examined O-GlcNAcylation and hyaluronan production, both of which draw from the same UDP-GlcNAc pool as N-linked glycosylation, and observed a mild decrease in the brain for both pathways”
Through spatial multiomics, spatial stable isotope tracing and retrospective cohort analyses, this study identifies hyperglycosylation as a driver of Alzheimer’s disease and a promising therapeutic ta...
