Congrats to Katie et al and special thanks to our collaborators in the Plate lab at Vanderbilt (TPP), and Irish Lab at U Colorado (flow)
This facilitated structure-activity relationship, verifying their potency against leukemia cell lines and the importance of the beta-lactone for cytotoxicity.
Natural products containing beta-lactones are covalent protein modifiers, & their unknown mechanism and electrophilic nature got us curious about their mechanism.
Using genome mining, and our single cell Multiplexed Activity Metabolomics, we identified a new producer and isolated a family of SBLs.
Brian O. Bachmann
Brian O. Bachmann
Brian O. Bachmann
Given the importance of RNA splicing to many cancers, we are continuing to work on identification of a discrete molecular target for SBLs to explain these data. Stay tuned!
In vitro reconstruction study providing cool new insights into "AT-less" PKS. Internal KSo domains for non-elongating modules. #natprod
www.nature.com/articles/s41...
