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In vitro reconstruction study providing cool new insights into "AT-less" PKS. Internal KSo domains for non-elongating modules. #natprod www.nature.com/articles/s41...
1mo
Decarboxylative condensation is essential for polyketide and fatty acid biosynthesis, yet the mechanism underlying nonelongating modules without this step remains elusive. Here the authors report a co...
www.nature.com
Condensation-independent intramodular translocation mechanism of the trans-AT polyketide synthase assembly line - Nature Chemical Biology
Our latest paper ‘Ecological context for bacterial natural products’ is now out in the Royal Society of Chemistry @natprodreports.rsc.org International effort with @jonathanparra.bsky.social, Marla I Macias-Contreras & Dulce Guillen Matus #puravida #naturalproducts pubs.rsc.org/en/Content/A...
Brian O. Bachmann
6d
Congrats to Katie et al and special thanks to our collaborators in the Plate lab at Vanderbilt (TPP), and Irish Lab at U Colorado (flow)
Given the importance of RNA splicing to many cancers, we are continuing to work on identification of a discrete molecular target for SBLs to explain these data. Stay tuned!
2mo
We used a flow cytometry to investigate potential mechanistic possibilities of SBLs e induction showing inhibition of phospho-signaling related to nutrient signaling.