Excited to share our new @cp-immunity.bsky.social review, discussing how advances in functional genomics and chemical biology are enabling the translation of IBD genetics into mechanistic understanding and new therapeutic hypotheses.
www.cell.com/immunity/ful...
#IBD #inflammatoryboweldisease
It's that time of year again--we are saying goodbye to more of our youngest and brightest lab members as they transition to the next steps of their careers, either in grad school or in other institutions. This week, we are saying goodbye to Anna, Regan, and Tanvi.
Good luck at UCSF (Anna), University of Washington (Regan), and MIT (Tanvi). We will miss you!
New website launch for the World Diet Initiative—an international effort to map global dietary patterns and their impacts on human health.
The site is now accepting heritage diet submissions to build the open-access World Diet Atlas.
www.worlddietinitiative.org
Out now in @cp-cellhostmicrobe.bsky.social! In collaboration with Swiss clinicians, we built the largest nasal microbial gene atlas in infants w/ and w/o cystic fibrosis to date (cont.)
Congratulations to postdoc Sacha Lebon on publishing his graduate work! Using single-cell profiling, his study reveals how intestinal epithelial stem cells sense and respond to bacterial invasion.
www.nature.com/articles/s41...
We found and validated in vitro that early-life perturbations (hypertonic saline inhalation therapy) can select for microbial traits linked to salt and antibiotic tolerance.
www.cell.com/cell-host-mi...
#antibiotics
#cysticfibrosis
#microbial
@broadinstitute.org @mgbresearch.bsky.social
Excited to share this new preprint from a large collaborative effort using #exome + #genome sequencing, moving beyond GWAS to implicate 68 genes in #IBD through rare protein-coding variation.
bit.ly/43h72GA
@broadinstitute.org
@mgbresearch.bsky.social