It's that time of year again--we are saying goodbye to more of our youngest and brightest lab members as they transition to the next steps of their careers, either in grad school or in other institutions. This week, we are saying goodbye to Anna, Regan, and Tanvi.
Early-life interventions & airway microbiome
Nasal microbial gene atlas in infants w/cystic fibrosis. Hypertonic saline inhalation reshapes microbiome, selects salt-tolerant H. influenzae & ⬆️transporters linked to antibiotic tolerance @thexavierlab.bsky.social
www.cell.com/cell-host-mi...
Congratulations to postdoc Sacha Lebon on publishing his graduate work! Using single-cell profiling, his study reveals how intestinal epithelial stem cells sense and respond to bacterial invasion.
www.nature.com/articles/s41...
Good luck at UCSF (Anna), University of Washington (Regan), and MIT (Tanvi). We will miss you!
What the nose knows of cystic fibrosis microbes and hypertonic saline
Bouzek Previews work by @thexavierlab.bsky.social presenting microbial gene atlas of nasopharyngeal swabs in infants w/cystic fibrosis & healthy controls & IDing impacts of clinical interventions
www.cell.com/cell-host-mi...
Out now in @cp-cellhostmicrobe.bsky.social! In collaboration with Swiss clinicians, we built the largest nasal microbial gene atlas in infants w/ and w/o cystic fibrosis to date (cont.)
We found and validated in vitro that early-life perturbations (hypertonic saline inhalation therapy) can select for microbial traits linked to salt and antibiotic tolerance.
www.cell.com/cell-host-mi...
#antibiotics
#cysticfibrosis
#microbial
@broadinstitute.org @mgbresearch.bsky.social