GBM Lunch on May 6, 2026, 12:30
Speaker: Youjun Yang (East China University of Science and Technology)
Title: "Early Ferroptosis Detection Targeting Lipid Hydrogen Abstraction”
Chair: @oliverthornseshold.bsky.social
Organizer: Joint Study Group "Chemical Biology"
#GBMLunch #ChemicalBiology
We tested a way to selectively increase delivery of nano-formulated drugs into solid tumours by disrupting their immature blood vessel system.
In a syngeneic mouse model for TNBC (4T1) we combined
💊 clinically approved nano-formulated drug
💉 low-dose small molecule microtubule destabiliser (CA4P)
What happened?
🎯 We made sure that all tumours were large enough to be neo-vascularised at the start of treatment
⏩ fast forward to 2nd/3rd treatment: no CA4P-dependent drug accumulation inside tumours anymore.