What membrane properties do cells maintain through regulation of lipid metabolism? In a new paper, we identify intrinsic curvature stress as one such parameter and show how different (eukaryotic) cell types employ different lipids to do that www.cell.com/cell-reports...
Truly mind-blowing how a novel cellular structure hid right behind our noses - and an impressive journey from initial observation to mechanism!
New paper where we report that Npc2 - a shuttle-like lipid transfer protein - in yeast directly transports sphingolipids to the = vacuole membrane during formation of microautophagy-linked ordered domains #lipidtime
www.sciencedirect.com/science/arti...
GBM Lunch on June 17 (12:30 pm)
Speaker: Nora Vögtle (@zmbh.uni-heidelberg.de)
Title: Sensing and shaping mitochondrial function: Proteolytic control and stress surveillance
Chair: Johannes Herrmann (RPTU)
Organizer: GBM Study Group "Cellular Organelles" #Mitochondria #GBMLunch #Organelles
What a joy to defend my PhD and kiss the Gänseliesel last Friday! Crazy to think that this is the moment I've been working towards since setting foot in the Department as a small Master's student in 2020. Thanks to Stefan and all the Jakobs lab members past and present who were part of this journey!
How much does it cost to buy your way onto a scientific paper?
To answer this question (and better understand the global market for academic reputation manipulation), we compiled BuyTheBy, a massive dataset of thousands of advertisements from paper mills in seven different countries.
Link below!
Excessive fatty acid oxidation selectively depletes 18:1 and 18:2 fatty acids needed for cardiolipin remodelling - does that mean that mitochondria literally eat themselves?
We are hiring a PhD student or PostDoc in the field of understanding and manipulating ubiquitin ligase specificities at @sonjalorenzlab.bsky.social.
📅 The positions should be filled as soon as possible.
👉 More info: www.mpinat.mpg.de/19-26?c=2501...
We're hiring! 🔬🏔️ Looking for curious, open-minded, and multidisciplinary #PhD candidates to research at the intersection of #mitochondria, #metabolism, #imaging & #physiology, with the #Alps as a backdrop. Sounds like you or someone you know? Link below!
@fbm-unil.bsky.social @unil.bsky.social
Going through some old microscopy data, and I have to say - I maintain that #mitochondria are the most beautiful organelles, but the #ER might be a very close second.
#FluorescenceFriday
Live HeLa cells, ER imaged by STED, mitochondria with confocal.
The yeast vacuole membrane forms ordered microdomains that facilitate microlipophagy under nutrient limitation. We previously found that this process …
www.sciencedirect.com
Cells maintain membrane function by actively balancing the molecular shape of their
lipids. Milshteyn et al. find that, when subjected to high hydrostatic pressure, yeast
and human cells, but not bact...
GBM (Gesellschaft für Biochemie und Molekularbiologie)
Reese Richardson
Juan C. Landoni
Jannis Anstatt
Check out our new release on BioRxiv
co-lead by @pm-mueller.bsky.social
👉 rb.gy/lnrizk
special🙏 to
Severine Kunz #MDC
@leventallab.bsky.social
@andimicroscopy.bsky.social
@ewerslab.bsky.social and Kedar Narayan @NCI CCR VolumeEM
Are the days of discovering new cellular structures over?? /1
A landmark in cardiac metabolism: doi.org/10.1172/JCI2...
Jay D. Horton & team find unrestrained fat oxidation in heart cells deplete cardiolipins needed for mitochondrial energy, triggering heart failure in mice and revealing a potential metabolic target
MPI for Multidisciplinary Sciences
Video
The Landoni Lab opens this summer at UNIL! @fbm-unil.bsky.social 🔬 Quantitative #imaging + systems biology to decipher how #metabolic architecture & #mtDNA dynamically shape tissue development, #aging and #mitodisease. Beyond excited to fire up the lasers, open positions soon! 🧪 #mitochondria #newPI
