Excessive fatty acid oxidation selectively depletes 18:1 and 18:2 fatty acids needed for cardiolipin remodelling - does that mean that mitochondria literally eat themselves?
Jannis Anstatt
A landmark in cardiac metabolism: doi.org/10.1172/JCI2...
Jay D. Horton & team find unrestrained fat oxidation in heart cells deplete cardiolipins needed for mitochondrial energy, triggering heart failure in mice and revealing a potential metabolic target
