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Why do we lose so much talent in academia? Let’s talk about it – openly, together, responsibly. NEXT TUESDAY AT 5:30 PM. PI Forum Brno #7 | Feb 3 @ CEITEC MU For all PIs, PhDs & researchers in Brno. Chaired by @fabianlab.bsky.social
New Paper Alert! 1982: WNT discovered 1990s: NOTCH enters the stage 2000s: “Let’s study pathways separately.” 2025: “Actually, they talk to each other.” Welcome to the era of WNT-NOTCH crosstalk Great collaboration with Mašek lab (CZ) and G. Collu (US) royalsocietypublishing.org/rsob/article...
4mo
4mo
So proud of my team. Talented, hardworking, growing every day. Being there for them is my biggest joy. Harnos Lab 2026 🐸 😍 🥳
Abstract. Multicellularity emerges from the ability of cells to undergo functional differentiation. One of the key mechanisms that enables this coordinatio
Decoding ‘Wntch’: the intertwined Wnt and Notch pathways in development and disease
royalsocietypublishing.org
3mo
Jakub Harnos lab
Jakub Harnos lab
Together with @harnoslab.bsky.social, we compiled what is known about direct interactions of Wnt and Notch components, and advanced the testable framework of how the crosstalk could allow for a more polarized cellular response to one pathway or the other.
Jakub Harnos lab
A new Master is born 🎓 Kristýna finished her Master’s degree in the Harnoš lab 🔬 Our fourth Master - congratulations 🚀
🐸 Amphibians take over Europe!! 📍 Prague. July 3–5, 2026. The European Amphibian Conference 2026 is coming: 3 days of cutting-edge science, bold ideas, iconic speakers, and serious frog & axolotl energy ✨ 👉 Register. Submit. Be there. Do not miss it. amphib-conf2026.sciencesconf.org?lang=en
4mo
Welcome to Brno 🇨🇿 Our two new exchange students, Alba Macipe Feito and Ana Moreno Llorente 🇪🇸 They will study molecular and cell signalling for the following four months 🔬 Good luck and godspeed 🚀
4mo
4mo
4mo
🧪🐸 PhD position open in the Harnos Lab (Masaryk University, Brno)! We study cell migration, WNT/PCP signaling, mitochondria & energy in Xenopus. Start: June 2026 (flexible) Apply by Feb 28, 2026 📩 [email protected] #PhDposition #CellBiology #Mitochondria #Xenopus #WNT #PCP
Just published a #BehindThePaper blog post about our new paper on PRICKLE3 and WNT/PCP signalling! 🧬 Check out the story behind the science and what we learned along the way 👇 communities.springernature.com/posts/behind...
When you urgently need the restroom but get lost in a Xenopus development poster instead… 🐸🧠 Thanks to my lab heroes Lorena & Douglas for representing the #DaysOfOpenDoors at Masaryk University #frogpower #MUNI
5mo
5mo
Jakub Harnos lab
Jakub Harnos lab
Jakub Harnos lab
5mo
Jakub Harnos lab
Jakub Harnos lab
Behind every research paper, there is a long story that is usually invisible to the reader. Our paper is no exception. What began as a focused cell biology project gradually developed into a broad, co...
communities.springernature.com
Jakub Harnos lab
Behind the Paper: How PRICKLE3 Found Its Place in WNT/PCP Signalling
🔥 New paper out! PRICKLE3 is not just another PRICKLE. It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species. Big mechanism. Big fun. 🐸🔥 www.nature.com/articles/s42...
Jan Mašek
5mo
We mapped PRICKLE1–3 interactomes and identified PRICKLE3 as a key WNT/PCP regulator that stabilizes VANGL via CK1ε–RNF43 control, revealing a PRICKLE3-specific mechanism shaping polarity across verte...
www.nature.com
PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation - Communications Biology
Jakub Harnos lab