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🔥 New paper out! PRICKLE3 is not just another PRICKLE. It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species. Big mechanism. Big fun. 🐸🔥 www.nature.com/articles/s42...
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We mapped PRICKLE1–3 interactomes and identified PRICKLE3 as a key WNT/PCP regulator that stabilizes VANGL via CK1ε–RNF43 control, revealing a PRICKLE3-specific mechanism shaping polarity across verte...
www.nature.com
PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation - Communications Biology
Jakub Harnos lab