Just published a #BehindThePaper blog post about our new paper on PRICKLE3 and WNT/PCP signalling! 🧬 Check out the story behind the science and what we learned along the way 👇
communities.springernature.com/posts/behind...
Behind every research paper, there is a long story that is usually invisible to the reader. Our paper is no exception. What began as a focused cell biology project gradually developed into a broad, co...communities.springernature.com
🔥 New paper out!
PRICKLE3 is not just another PRICKLE.
It stabilizes VANGL, blocks CK1ε phosphorylation, suppresses RNF43, and rewires WNT/PCP signaling across species.
Big mechanism. Big fun. 🐸🔥
www.nature.com/articles/s42...
We mapped PRICKLE1–3 interactomes and identified PRICKLE3 as a key WNT/PCP regulator that stabilizes VANGL via CK1ε–RNF43 control, revealing a PRICKLE3-specific mechanism shaping polarity across verte...
