Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS
Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab
colab.research.google.com/github/KULL-...
And just a month after the publication Daniel Erlanson has kindly highlighted it in the Practical Fragments blog. I think this is the third time our work has made it to the blog - must be a sign of us doing at least some things right.
practicalfragments.blogspot.com/2026/06/an-u...
Here is the paper in @biochemsoc.bsky.social Bioscience Reports:
portlandpress.com/bioscirep/ar...
Just out is a little cautionary tale by @emmabelcher96.bsky.social
Turns out StrepTactin pulls down biotinylated proteins from mammalian cells and anti-FLAG antibody likes its own specific contaminants. Both of which can end up dominating your precious cryo-EM images.
You've been warned!
I'm attending a digital humanities event in Montreal. There was a keynote on AI and something about the talk made me wonder if it had been written by Claude. I said as much in the Q&A. As I posed the question, the speaker shifted, looking slightly uncomfortable. What he said next shocked the room +
Congratulations to the @markohyvonen.bsky.social Group on its celebration of 25 years this week by 40 alumni! Since 2001, it has welcomed 21 Postdocs, 8 RAs, 15 PhDs, 6 Visiting PhDs, 9 MScs and 46 Undergrads and contributed over 90 publications. 🎂🎉👏 Read more: www.bioc.cam.ac.uk/news/hyvonen...
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes:
🖌️ Dozens more images with duplications or painting
🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Here is the paper itself if you want to take a peak.
doi.org/10.1021/acs....
Ok, time to get back on this platform with some science, as exciting things are coming out. Well, I think they are exciting.
Let's start with cool FBDD story.Together with Spring group we have come up with a covalent inhibitors for PH domain. Activated lysine in PIP3 binding site, it seems.