Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
Petr Skopintsev
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
A beautiful study from the Pausch lab!
Video
My main postdoc paper repost marked as spam - just for the memories. Shame, shame @moderation.bsky.app! 😀
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to @isabelesain.bsky.social, @evandeturk.bsky.social, @doudna-lab.bsky.social, @jacobsenucla.bsky.social, @jhdcate.bsky.social, @banfieldlab.bsky.social, @innovativegenomics.bsky.social!
Doudna Lab
Petr Skopintsev
Petr Skopintsev
Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure.
We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)
Petr Skopintsev
Patrick Bryant
New paper from my group in @science.org : "A small polymerase ribozyme that can synthesise itself and its complementary strand" www.science.org/doi/10.1126/...
Outstanding work by @edogia.bsky.social
New online: Structure and mechanism of antiphage retron Eco2
Can we simulate realistic evolutionary trajectories and “replay the tape of life”? In this work, we propose a flexible, generalizable deep learning framework for modeling how the entire protein sequence evolves over time while capturing complex interactions across sites. 1/n
doi.org/10.64898/202...
Phil Holliger
A very nice Preview of our work in
@cp-cellhostmicrobe.bsky.social
this morning from Chrishan Fernando & Nicole D. Marino! www.cell.com/cell-host-mi...
doi.org
www.cell.com
Across all domains of life, immune systems rely on nucleotide-based signaling molecules
to activate defense responses. In a recent Cell Host & Microbe study, Doherty, Nomburg,
and colleagues identify ...
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
Video
Doudna Lab
1/6) Hot off the press @natsmb.nature.com 🔥! Jasnauskaite et al. reveal how the minimal bacterial retron Eco2 defends against #phage 🛡️. Phage nucleases trigger Eco2, which cuts RNA, shuts down protein production and stops phage replication 🦠🚫. #phagesky #immunity #microbiology #cryo-em rdcu.be/e4AyH
Patrick Pausch
dlvr.it
Nature Structural & Molecular Biology, Published online: 18 February 2026; doi:10.1038/s41594-026-01754-2This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein production and stops phage replication.
Nature Structural & Molecular Biology - This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein...
