We present VIPR, a phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR.
Tiny, programmable, possibly ancestral to CRISPR immunity; VIPR is built around a striking RNA-DNA-DNA triplex.
Doudna Lab
New pre-print 📣 “Undruggable” cancer mutations remain very hard to target with current modalities. What if we could instead sense mutant transcripts and convert that recognition into selective cell killing?
Check out this work led by postdoc Jingkun Zeng:
www.biorxiv.org/content/10.6...
Hello world! I am excited to announce my lab is open at the University of Utah in the Department of Biochemistry. We are looking for scientists at all levels interested in studying host-virus interactions in both bacteria and animals. Come join us in beautiful Utah! (photo is 10 steps from lab)
New preprint: Cyclic tri-adenylate signalling by a Panoptes anti-phage guard system with a CARF-TM effector. Great work led by Sabine GrĂĽschow
www.biorxiv.org/content/10.6...
"What we’re … seeing is the toll of the uncertainty."
My latest story for @science.org—part of a package that explores how the U.S. scientific community has changed under Trump—includes new numbers on graduate enrollment and faculty hiring.
www.science.org/content/arti...
Friends, please help spread the word about our microbiology REU program at Montana State University.
www.montana.edu/mbi/reu/
Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided.
Details in the attached pic--Feb 14 deadline
🧫🧪🦠#microsky
www.biorxiv.org
Doudna Lab
Interested in microbiology, immunology, and host-pathogen interactions? Come work with us!
Our department at OHSU is opening a search for a new tenure-track faculty position. See the job advertisement for details.
Please share within your networks!
www.nature.com/naturecareer...
Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes
www.science.org/doi/10.1126/...
Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration!
Linking below previous thread on our findings
Amazing work from my talented lab-mates. Check out this phage-encoded RNA-guided system that recognizes DNA with a noncontiguous code unlike CRISPR.
The Department of Molecular Microbiology and Immunology at OHSU invites applications for a tenure-track Assistant or Associate Professor position.
Immune systems in animals, plants, and bacteria often rely on intracellular nucleotide signaling, which viruses can block by sequestering or degrading these signals. We identified structural and bioph...
Our lab is proud to present our latest work harnessing Bridge Recombinase for genome-scale editing in diverse bacteria, microbiome editing, and programmable horizontal gene transfer.
Sam Hobbs
Erin Doherty
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.
We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.
Thread + link below.
Malcolm White
Katie Langin
Patrick R. Secor
Jonathan Pruneda
Sorek Lab
Kenneth Loi
📢Preprint out!
Excited to share my final work from the @soreklab.bsky.social!
We mined phage dark matter using structural features shared by anti-defense proteins (viral tools that help phages bypass bacterial immunity) to guide discovery.
Found 3 new families targeting immune signaling!
Cress Lab
Nitzan Tal
Bridge recombinase enables versatile rewriting of bacterial genomes https://www.biorxiv.org/content/10.64898/2026.04.29.721476v1
