⚙️ A Bipartite Evolutionary Mode
The eukaryotic proteome isn't a uniform soup.
We resolve it into two distinct modes:
A rigid "Architectural Core" (Cytoskeleton/Chaperones)
A highly plastic "Operational Engine" (Metabolism/Translation) (3/5)
The future of drug design is in AI. RareFoldGPCR: Agonist Design Beyond Natural Amino Acids.
Paper: www.biorxiv.org/content/10.1...
Code: github.com/patrickbryan...
🕊️ Structural Acceleration
Does a bigger genome mean faster structural evolution? No.
We found lineage-specific bursts of structural innovation in Birds (Aves) and Ants (Hymenoptera) that are distinct from genomic expansion. (4/5)
Huge congrats to lead authors Qiuzhen Li & Diandra Daumiller! Thanks to @martinsteinegger.bsky.social for all the great tools!
📄 Preprint: biorxiv.org/content/10.6...
🖥️ Try the Tool: she-app.serve.scilifelab.se
Job alert🚨 Postdoc (Computational Proteomics × Plant Immunity) 🌱
Join us to build a cross-species plant pan-terminome & study proteolysis in immunity with excellent collaborators: Bernhard Kuester, Mathias Wilhelm, @degradomics.bsky.social, Patrick Willems, @patrickbryant1.bsky.social
Please RT 🙏
🐁 Stop guessing your model organism.
Our new search engine allows you to rank model organisms by their structural fidelity to specific human pathways.
Case Study: For Fanconi Anaemia, Mouse is perfect. Yeast fails. C. elegans is a hidden gem. (2/5)
This is the first study from my lab - providing the first PoC for both linear and cyclic untargeted binder design! EvoBind is available here: github.com/patrickbryan...
Update: RareFold 🧬
Our AI framework for protein design with 29 noncanonical AAs now shows designed binders (linear + cyclic) are non-immunogenic in patient-derived assays — paving the way for safe next-gen peptide therapeutics.
👉https://www.biorxiv.org/content/10.1101/2025.05.19.654846v2
Our study where we develop EvoBind2: Design of linear and cyclic peptide binders from protein sequence information is now published! www.nature.com/articles/s42...
Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure.
We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)
