My foray into video creation! This is my entry into #SoME4, an annual exposition of math-explainers. A friendly introduction to hypothesis testing, with minimal math background required.
www.youtube.com/watch?v=qEE0rzytHls
I will be speaking about this work next week at the Probabilistic Modeling in Genomics conference in Berkeley on Thursday @ 11:30 am. If you’re attending, come and say hi!
Most p-value explanations that I've come across focus only on the mechanical process of calculation, without telling students why they're doing it or how to interpret the results. So this video is me attempting to motivate the concept of hypothesis testing from first principles.
We also present a simplified model of QTL discovery, suggesting that caQTL sensitivity more easily captures regulatory variants than eQTLs at constrained genes. Since GWAS hits are enriched at these genes, caQTLs can supplement eQTLs in interpreting the molecular mechanisms of trait heritability.