How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”.
www.biorxiv.org/content/10.6...
We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.
Now online! Single-cell mapping of regulatory DNA-protein interactions
Europe is stepping up, helping Ukraine for the right moral reasons and helping their mutual economies.
The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...
🔗 doi.org/10.64898/202...
Today marks 4th anniversary of Russia's invasion of Ukraine. Russia is responsible for over 200,000 war crimes, killing over 15,000 civilians and displacing millions. My heart breaks for every Ukrainian. I continue attending rallies and donating hoping one day Ukraine will be free and safe.
