Europe is stepping up, helping Ukraine for the right moral reasons and helping their mutual economies.
Now online! Single-cell mapping of regulatory DNA-protein interactions
New study led by Ning Shen w/ @phruzycki.bsky.social: a genome-wide in vivo CRISPR screen in a retinitis pigmentosa mouse model identifies genes whose loss accelerates photoreceptor death. Overexpressing two, UFD1 and UXT, preserves photoreceptors, retinal function, and vision. 🧵
How do pleiotropic TFs generate organized diversity in developing tissues? @spinalorga.bsky.social shows that PAX3 & PAX7 organize #SpinalCord by acting as both repressors & pioneer activators, regulated by #morphogens to ensure precise neural subtype specification @plosbiology.org 🧪 plos.io/4qumsla
D&D-seq, a single-cell immune-tethering strategy, captures weak and transient DNA-protein interactions to enable integrated, genome-wide analysis of transcription factor binding across chromatin states.
Today marks 4th anniversary of Russia's invasion of Ukraine. Russia is responsible for over 200,000 war crimes, killing over 15,000 civilians and displacing millions. My heart breaks for every Ukrainian. I continue attending rallies and donating hoping one day Ukraine will be free and safe.
The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...
🔗 doi.org/10.64898/202...
Exciting to see it published! I had a lot of fun using AlphaGenome since the preprint. Congratulations!