Group leader and Wellcome Sir Henry Dale Fellow based at the Centre for Human Genetics at Oxford University. Interested in genomics, single-cell technologies, 3D DNA folding and chromatin disruption in human disease. He/him.
Rob Beagrie
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New preprint from @anadopico.bsky.social (who I have had the great pleasure of supervising with Tom Milne) and our fantastic collaborators in the @davieslab.bsky.social
www.biorxiv.org/content/10.6...
#genomics #GeneRegulation #chromatin
Ana shows that degradation of the histone chaperone FACT causes nucleosome loss at active gene promoters and spreading of chromatin binding factors into gene bodies. New ultra-long promoter-promoter interactions also form, including this mammoth one between Sox2 and Tiparp that spans nearly 30 Mb!
This is a common reply to concerns about GenAI research as if it were just another computational tool that saves us times from tedious tasks and whose accuracy can be rigorously quantified.
It is not.
GenAI research poses at least 2 serious problems... /n
New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.
Although cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social
www.biorxiv.org/content/10.6...
Very pleased to say that the paper version of our study examining the role of de novo DNMTs in cancer-associated hypomethylation is now out in @plos.org Genetics 🎉:
doi.org/10.1371/jour...
You can read more on the previous thread but here is a summary of the main updates! #epigenetics 🧵 1/9
I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...
www.biorxiv.org
“It is not acceptable to recruit a variety of students into the laboratory, subject them to a variety of stress tests and abuses, and then keep the students who thrive under abuse and get rid of the students who aren't able to thrive in the lab. That's straight-up exploitation.”
👏👏👏
Rob Beagrie
Rob Beagrie
This is probably my favorite paper of 2025. Beautiful work by @elphegenoralab.bsky.social and @karissalhansen.bsky.social that should be on the top of the reading list for everyone with even a slight interest in gene expression!
Wendy Bickmore
One frame. Many voices. ✨
This International Women’s Day, our Women in Science series features group leader Christa Bücker 🙌
Today, @chribue.bsky.social shares an important perspective on finding role models and becoming one for the next generation 👩🔬
@univie.ac.at
@meduniwien.ac.at
Jeremy Van Cleve
Duncan Sproul
Miguel Branco
Ben Sabari
Jessica Reid 🌈
Christa Buecker
I keep coming back to Kevin Bryan's point: "I get the desire for artisanal, hand-crafted research, with the matrices hand-inverted. But our job is to move the frontier of knowledge, not self-actualization."
I personally don't care if something is done by humans or AI, I want it to be accurate.
New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1...
For a quick summary see this 🧵 1/8 #epigenetics
Duncan Sproul
Alexander Kustov
You know those labs that keep harming students, again and again? Some reflections on why it's so hard to stop this from happening and where our responsibilities lie.
scienceforeveryone.science/bad-mentors-... 🧪
Loss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability. Cancer-...
