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New pre-print alert 🚨 Interested in what @ikafetzo.bsky.social learned about DNA hypomethylation in cancer from investigating surprising gains DNA methylation in DNMT1 KO cells? Read all about it here: www.biorxiv.org/content/10.1... For a quick summary see this 🧵 1/8 #epigenetics
Jan 9, 2025
Loss of DNA methylation is a hallmark of cancer that is proposed to promote carcinogenesis through gene expression alterations, retrotransposon activation and induction of genomic instability. Cancer-...
DNMT1 loss leads to hypermethylation of a subset of late replicating domains by DNMT3A
www.biorxiv.org
Duncan Sproul