Proud of this collaboration - our third paper on cisPT! Loved this one the most: a beautiful mix of high-res, low-res, and computational approaches. Grateful for this long-standing, truly fruitful team effort. Congrats to everyone!
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in
@NatureComms
, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in
@NatureComms
, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
peterslab (BIOCEV,CZ)
rdcu.be
Nature Communications - This study shows how the NgBR subunit controls the activity of human cis-prenyltransferase, a key enzyme for protein glycosylation. Combined experimental and computational...
Nature Communications - This study shows how the NgBR subunit controls the activity of human cis-prenyltransferase, a key enzyme for protein glycosylation. Combined experimental and computational...
Great collaboration (as always)! And very funny story how HDX and native MS complement each other and reveal details about ions, substrates and mutations. We enjoyed this ride!
Hi!
Correct DOI here:
doi.org/10.1002/pro....
Correct DOI here:
doi.org/10.1002/pro....
A huge Thank You to all the collaborators who contributed to this fun project: Udi Qimron, @haitinlab.bsky.social, @bursteinlab.bsky.social, and congrats to the first author
@tridibmahata.bsky.social !
An open question remains - where will this be published? 😏
Video
peterslab (BIOCEV,CZ)
doi.org
Flexible proteins populate heterogeneous conformational ensembles that are essential for their function. Small-angle x-ray scattering (SAXS) is widely used to study protein structure in solution and ...
Flexible proteins populate heterogeneous conformational ensembles that are essential for their function. Small-angle x-ray scattering (SAXS) is widely used to study protein structure in solution and ...
doi.org
ALT: two men are sitting next to each other and one of them is saying teamwork
Excited to share our new paper in @febsj.bsky.social! 🎉
We show how a #MYELOMA-linked GGPPS mutation tweaks hexamerization, substrate binding and product inhibition, revealing an unexpected layer of protein prenylation regulation
🔗 doi.org/10.1111/febs...
@peterslab1.bsky.social
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic mult...
Excited to share our new paper in @proteinsociety.bsky.social 🎉
We combine #BioEmu and SAXS ensemble optimization to characterize protein conformational heterogeneity, bridging AI-generated ensembles and experimental data.
doi.org/10.1002/pro.70…
#SAXS #MachineLearning
Grateful to our fantastic collaborators @peterslab1.bsky.social and @AlbGiacomello on this journey! @telavivuni.bsky.social @TAUMedFaculty @of_sagol @SouraskyMedCtr
#Biochemistry #StructuralBiology
Excited to share our new paper in @proteinsociety.bsky.social 🎉
We combine #BioEmu and SAXS ensemble optimization to characterize protein conformational heterogeneity, bridging AI-generated ensembles and experimental data.
doi.org/10.1002/pro.70…
#SAXS #MachineLearning
