Proud of this collaboration - our third paper on cisPT! Loved this one the most: a beautiful mix of high-res, low-res, and computational approaches. Grateful for this long-standing, truly fruitful team effort. Congrats to everyone!
A huge Thank You to all the collaborators who contributed to this fun project: Udi Qimron, @haitinlab.bsky.social, @bursteinlab.bsky.social, and congrats to the first author
@tridibmahata.bsky.social !
An open question remains - where will this be published? 😏
Hi!
Excited to share our new paper in @proteinsociety.bsky.social 🎉
We combine #BioEmu and SAXS ensemble optimization to characterize protein conformational heterogeneity, bridging AI-generated ensembles and experimental data.
doi.org/10.1002/pro.70…
#SAXS #MachineLearning
Grateful to our fantastic collaborators @peterslab1.bsky.social and @AlbGiacomello on this journey! @telavivuni.bsky.social @TAUMedFaculty @of_sagol @SouraskyMedCtr
#Biochemistry #StructuralBiology
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in
@NatureComms
, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
Excited to share our new paper in @proteinsociety.bsky.social 🎉
We combine #BioEmu and SAXS ensemble optimization to characterize protein conformational heterogeneity, bridging AI-generated ensembles and experimental data.
doi.org/10.1002/pro.70…
#SAXS #MachineLearning
doi.org
peterslab (BIOCEV,CZ)
Dor Salomon
HaitinLab
HaitinLab
doi.org
HaitinLab
HaitinLab
Great collaboration (as always)! And very funny story how HDX and native MS complement each other and reveal details about ions, substrates and mutations. We enjoyed this ride!
Flexible proteins populate heterogeneous conformational ensembles that are essential for their function. Small-angle x-ray scattering (SAXS) is widely used to study protein structure in solution and ...
doi.org
doi.org
Flexible proteins populate heterogeneous conformational ensembles that are essential for their function. Small-angle x-ray scattering (SAXS) is widely used to study protein structure in solution and ...
🚨It's finally out!🥂 | A few years after solving the structure of human cis-PT, we now tackle its dynamics in
@NatureComms
, revealing that a conserved interfacial loop serves as an allosteric hub, communicating with the active site to regulate catalysis. rdcu.be/eShjl
Video
HaitinLab
ALT: two men are sitting next to each other and one of them is saying teamwork
