Excited to share that our paper is out in @natneuro.nature.com, presenting a multi-omic atlas and high-throughput morphogen screen of human organoids modeling the posterior brain! 🧠
nature.com/articles/s41...
@zhisonghe.bsky.social @hsiuchuanlin.bsky.social @TreutleinLab @graycamplab.bsky.social
New from the lab: BARseq3!
Barcodes + high efficiency spatial transcriptomics and translatomics in the same cells, or just a nice spatial transcriptomics assay. All in a modular, expandable system to enable truly multimodal measurements. Check it out:
www.biorxiv.org/content/10.6...
A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵
We’re looking for a technician to join our lab in Dresden - help manage the lab and work with us on a cool 'stem cell zoo' comparison projects! 🐁🚶♀️🦏🐒
Apply by May 21!
tud.link/wbqrwm
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
Latest from Shendure & Qiu labs (@cxqiu.bsky.social)
)! We combined a new 4M cell mouse whole embryo scATAC-seq atlas (E10-P0), millions of 'evolutionarily coherent' orthologs from 241 mammalian genomes (Zoonomia), and the CREsted CNN framework (@steinaerts.bsky.social).
Today in Nature Neuroscience we have published our exploration of neocortical development leveraging 100's of public datasets. You can interrogate the entire compendium of data at nemoanalytics.org/landing/neoc... and read the paper at www.nature.com/articles/s41....
Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6...
@idrm.ox.ac.uk @oxforddpag.bsky.social
New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"
Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?
rdcu.be/e7zx7
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
www.biorxiv.org
Gene expression is a fundamentally stochastic process, with randomness in transcription
and translation leading to cell-to-cell variations in mRNA and protein levels. This
variation appears in organis...
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
www.science.org
This link will take you to a page that’s not on LinkedIn
In development, cells navigate highly complex gene-regulatory landscapes to make fate
choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity,
and collective multi...
www.cell.com
Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...
🚨 #JobAlert: Lab Technician. Please share with your colleagues!
👩🔬The Ebisuya lab @ebisuyamiki.bsky.social is looking for an experienced technician in molecular & cell biology to join their interdisciplinary team. Apply now!
Learn more here 👉 tud.link/wbqrwm
🗓️Application deadline: May 21.
