Today in Nature Neuroscience we have published our exploration of neocortical development leveraging 100's of public datasets. You can interrogate the entire compendium of data at nemoanalytics.org/landing/neoc... and read the paper at www.nature.com/articles/s41....
A clear/significant finding derived from the single cell (sc) analysis of biological systems has been the realization that phenotypically homogeneous populations are heterogeneous at the level of gene expression (GE). www.cell.com/fulltext/S00... 🧵
New from the lab: BARseq3!
Barcodes + high efficiency spatial transcriptomics and translatomics in the same cells, or just a nice spatial transcriptomics assay. All in a modular, expandable system to enable truly multimodal measurements. Check it out:
www.biorxiv.org/content/10.6...
New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"
Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?
rdcu.be/e7zx7
Excited to share that our paper is out in @natneuro.nature.com, presenting a multi-omic atlas and high-throughput morphogen screen of human organoids modeling the posterior brain! 🧠
nature.com/articles/s41...
@zhisonghe.bsky.social @hsiuchuanlin.bsky.social @TreutleinLab @graycamplab.bsky.social
Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6...
@idrm.ox.ac.uk @oxforddpag.bsky.social
Latest from Shendure & Qiu labs (@cxqiu.bsky.social)
)! We combined a new 4M cell mouse whole embryo scATAC-seq atlas (E10-P0), millions of 'evolutionarily coherent' orthologs from 241 mammalian genomes (Zoonomia), and the CREsted CNN framework (@steinaerts.bsky.social).
www.biorxiv.org
Carlo Colantuoni
Alfonso Martinez Arias
Nadezhda Azbukina
We’re looking for a technician to join our lab in Dresden - help manage the lab and work with us on a cool 'stem cell zoo' comparison projects! 🐁🚶♀️🦏🐒
Apply by May 21!
tud.link/wbqrwm
Justus Kebschull
Jay Shendure
Filipa Simões
James Briscoe
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders?
In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸
🔗 www.science.org/doi/10.1126/... #EvoDevo
Miki Ebisuya
www.biorxiv.org
Why mammals cannot regenerate limbs like amphibians do presents a long-standing puzzle in biology. To uncover the underlying differences, we compared amputation responses of embryonic mouse (Mus musculus) and Xenopus laevis tadpole limbs. Lowering ...
Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...
Gene expression is a fundamentally stochastic process, with randomness in transcription
and translation leading to cell-to-cell variations in mRNA and protein levels. This
variation appears in organis...
In development, cells navigate highly complex gene-regulatory landscapes to make fate
choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity,
and collective multi...
🚨 #JobAlert: Lab Technician. Please share with your colleagues!
👩🔬The Ebisuya lab @ebisuyamiki.bsky.social is looking for an experienced technician in molecular & cell biology to join their interdisciplinary team. Apply now!
Learn more here 👉 tud.link/wbqrwm
🗓️Application deadline: May 21.
