Game over, phylogeneticists! New DNA foundation model "Carbon" reconstructs the tree of life. 🙃 huggingface.co/spaces/Huggi...
22/n On a personal note, I’ll soon start an independent research group in the Genome Biology Unit at EMBL Heidelberg. If you enjoy this type of work and want to engineer genomes at the largest scale, please reach out!
jonas-koeppel.github.io/koeppellab/
www.embl.org/groups/koepp...
NIH funded peeps:
This is insane and coming for us.
Genome engineering research led by Jonas Koeppel, developing scalable technologies to design structural variants and study mammalian genome function.
“AlphaFold 3's representational coherence is deeply tied to evolutionary scaffolding, suggesting it functions similarly to an advanced fold-recognition system and highlighting that protein structure prediction from sequence alone is not yet fully solved.”
www.biorxiv.org
Many long noncoding RNA–DNA binding peaks detected using common assays arise from technical artifacts.www.nature.com
This week’s launch of the #BrainHealth accelerator marks an important step forward for neuroscience. I’m excited to see this ambitious effort rally teams around a shared goal: building a deeper understanding of brain disease and accelerating progress toward better therapies.
Kurianlab
Jay Shendure
Brain disease is tragic, but it doesn’t have to be. It’s time for a new approach to #brainhealth research.
That’s why we and our partners are launching the Brain Health accelerator.
🎥 youtu.be/wnTG5Sg8AKY?...
How much of the human genome is essential?
Two pieces out today from our lab: 1) a method to map essential genomic intervals at gigabase scale, and 2) an argument that it's time to consider synthesizing a minimal human genome.
biorxiv.org/content/10.6...
nature.com/articles/d41...
And, here, in much more detail.
This is an absolutely critical read for all federally funded scientists and institutions.
Now is not the time to sit in the corner, hoping you won't be noticed - now is the time for action.
elizabethginexi.substack.com/p/summary-of...
YouTube video by allen institute
youtu.be
A decade on from the launch of an ambitious project, it’s time to revisit the reasons for constructing a human genome from scratch.
1/n What fraction of the human genome is essential for cells?
Excited to share our preprint that explores this question by combining an unusual CRISPR system, phage promoters, and thousands of deletion launchpads.
@sudpinglay.bsky.social @jshendure.bsky.social
www.biorxiv.org/content/10.6...
Brain disease is tragic, but it doesn’t have to be. It’s time for a new approach to #brainhealth research.
That’s why we and our partners are launching the Brain Health accelerator.
🎥 youtu.be/wnTG5Sg8AKY?...
