New on Vumedi: Dr. Jeffrey Freiberg discusses findings from the STOP-Vanc trial and the role of MRSA PCR nasal swab testing in guiding vancomycin de-escalation for ICU patients with suspected pneumonia.
Watch Now: www.vumedi.com/video/de-esc...
#InfectiousDiseases #AntimicrobialStewardship
Proud to see this published in @cidjournal.bsky.social & with an accompanying commentary!
Nasal decolonization = IP tool
MRSA nares = Abx stewardship tool
but what happens when they intersect?
Decolonization doesn’t limit usefulness of PCR testing within the first week!
What's Hot This Year in ID Clinical Science 2025
✅ Just Accepted
🔗 https://bit.ly/4t0iXEH
My thesis work has been a wealth of experience in #hostmicrobe biology, #MicrobialGenetics, and @microbesinfo.bsky.social that I look forward to sharing later this week! Thank you to the #mentors, collegaues, and #collaborators that worked with me the last 4 years! DM/comment for Zoom info!
Burden of Injection Drug Use-Related Infection Hospitalizations in Tennessee, 2016–2023
✅ Just Accepted
🔗 https://bit.ly/4c6Fh7Z
Jeff Freiberg
VuMedi Infectious Disease
Clinical Infectious Diseases
Staph papers
Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing
✅ Just Accepted
🔗 https://bit.ly/4bWBN9b
Kinda Surprising!
🆕💥🟢STOP-Vanc RCT
MRSA PCR nasal swab testing did not decrease the duration of vancomycin use or 30d mortality among ICU patients with suspected CAP,despite MRSA PCR nasal swab testing demonstrating a high NPV #idsky #EMIMCC
academic.oup.com/cid/article/...
Clinical Infectious Diseases
Open Forum Infectious Diseases
Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...
The NPV of MRSA PCR nasal swabs is not diminished after mupirocin decolonization. MRSA PCR testing within 7 days of initiation of decolonization is non-inferior to testing prior to decolonization.
β-lactam antibiotics are among the most widely used treatments for bacterial infections, yet therapeutic failure is common even when no genetic resistance is detected. Understanding how host factors...
t.co
Jonathan Ryder, MD
🔥Just published 🔥NEJM
SNAP RCT
In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky
www.nejm.org/doi/full/10....
www.nejm.org
Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...
In Tennessee, hospitalizations for injection-related infections disproportionately affected eastern Tennessee, and plateaued in 2018. Hospitalizations for
In this session, Dr. Jeffrey Freiberg reviews findings from the Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin (STOP-Vanc) randomized controlled trial. He explores the role of MR...
In this pragmatic randomized trial of 277 adults, vancomycin-free hours alive in the first 7 days of trial enrollment did not significantly differ between
