Aw🫰SNAP🫰
Cefazolin vs anti-staphylococcal PCN
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Caveats:
- FOREST was 100% bacteremic UTI
- A lower dose of oral fosfo was used (3g/48h).
- Definition of relapse was more strict, requiring a new isolation of E. coli with same phenotype.
- Absolute risk difference still low (11%), so definitely an option to consider if no other options!
#IDSky
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🆕💥🟢Among 305 episodes with suspected infective endocarditis and valve strands the majority did not represent IE.
Recurrence of IE due to the same microorganism within one year was significantly more frequent among episodes with IE compared to those without #idsky
academic.oup.com/cid/article/...
Two words
If there were PK/PD issues with fosfo, the problem might arise not on early TOC, but on relapses of non-cystitis UTI.
In this subanalysis of patients switched to oral in FOREST trial, more relapses were observed with fosfo for bacteremic E. coli UTI.
academic.oup.com/jac/article/... #IDSky #UTIsky