🔥Just published 🔥NEJM
SNAP RCT
In patients with MSSA bacteremia, cefazolin was noninferior to flucloxacillin or cloxacillin with respect to 90-day mortality and was associated with a lower incidence of acute kidney injury. #idsky
www.nejm.org/doi/full/10....
Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs?
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
New on Vumedi: Dr. Jeffrey Freiberg discusses findings from the STOP-Vanc trial and the role of MRSA PCR nasal swab testing in guiding vancomycin de-escalation for ICU patients with suspected pneumonia.
Watch Now: www.vumedi.com/video/de-esc...
#InfectiousDiseases #AntimicrobialStewardship
Kinda Surprising!
🆕💥🟢STOP-Vanc RCT
MRSA PCR nasal swab testing did not decrease the duration of vancomycin use or 30d mortality among ICU patients with suspected CAP,despite MRSA PCR nasal swab testing demonstrating a high NPV #idsky #EMIMCC
academic.oup.com/cid/article/...
Evaluation of the impact of universal mupirocin decolonization in intensive care units on the utility of MRSA PCR nasal swab testing
✅ Just Accepted
🔗 https://bit.ly/4bWBN9b
My thesis work has been a wealth of experience in #hostmicrobe biology, #MicrobialGenetics, and @microbesinfo.bsky.social that I look forward to sharing later this week! Thank you to the #mentors, collegaues, and #collaborators that worked with me the last 4 years! DM/comment for Zoom info!
Burden of Injection Drug Use-Related Infection Hospitalizations in Tennessee, 2016–2023
✅ Just Accepted
🔗 https://bit.ly/4c6Fh7Z
Proud to see this published in @cidjournal.bsky.social & with an accompanying commentary!
Nasal decolonization = IP tool
MRSA nares = Abx stewardship tool
but what happens when they intersect?
Decolonization doesn’t limit usefulness of PCR testing within the first week!
The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics
What's Hot This Year in ID Clinical Science 2025
✅ Just Accepted
🔗 https://bit.ly/4t0iXEH
Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus ...
Optimal cephalexin and cefadroxil dosing for skin and soft tissue infections (SSTIs) is unclear. We summarize clinical and pharmacokinetic/pharmacodynamic (PK/PD) data that compare dosing strategies ...
accpjournals.onlinelibrary.wiley.com
In this session, Dr. Jeffrey Freiberg reviews findings from the Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin (STOP-Vanc) randomized controlled trial. He explores the role of MR...
In this pragmatic randomized trial of 277 adults, vancomycin-free hours alive in the first 7 days of trial enrollment did not significantly differ between
In Tennessee, hospitalizations for injection-related infections disproportionately affected eastern Tennessee, and plateaued in 2018. Hospitalizations for
bit.ly
The NPV of MRSA PCR nasal swabs is not diminished after mupirocin decolonization. MRSA PCR testing within 7 days of initiation of decolonization is non-inferior to testing prior to decolonization.
pubmed.ncbi.nlm.nih.gov
β-lactam antibiotics are among the most widely used treatments for bacterial infections, yet therapeutic failure is common even when no genetic resistance is detected. Understanding how host factors...
