Excited to share an article that I've long awaited to share seeking to answer: What is the right dose of cephalexin/cefadroxil for SSTIs?
We reviewed clinical studies & conducted PTA sims to elucidate this #IDSky @absteward.bsky.social
accpjournals.onlinelibrary.wiley.com/doi/10.1002/...
REMAP-CAP domain on oseltamivir vs no-antiviral for patients admitted at ICU with influenza is stopped due to potential harm!
90d mortality:
Oseltamivir=19.4% (62/319)
No antiviral=13.7% (17/124)
Last word for oseltamvir?
What’s the rationale for harm? #IDSky
www.remapcap.org/oseltamivir-...
🔥The ARISE FLUIDS RCT
Among adults with septic shock, Restricted fluids + early vasopressors did not result in more days alive & out of the hospital through day 90 than liberal fluids + later vasopressors
Pulmonary edema (0.6% in the vasopressor group vs. 5.0% in the fluids group; P<0.001). #idsky
This was a truly multidisciplinary effort and cannot thank my co-authors enough. This was all inspired by a simple clinical question from @jeremytigh.bsky.social followed by a dive into the literature and it ran from there. @shawna-san.bsky.social, Sean Avedissian, @cortes-penfield.bsky.social et al
We also conducted PTA simulations and found its not too hard to achieve PTA for group A Strep across many dosing regimens, but its a bit harder to achieve PTA for MSSA at higher MICs, which is similar to what USCAST found
The clinical data of studies comparing doses is largely quite old and is fairly limited for various methodologic reasons, but generally shows similar outcomes between dosing strategies
We also look at the question of dosing these drugs in obesity, for which there is limited literature