An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below:
www.nature.com/naturecareer...
Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...
www.biorxiv.org
Postdoctoral Scientist Salary £42,694 per annum pro rata Fixed term for 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Applications are...
We are excited to be recruiting a new tenure track group leader in the Structural Studies Division at MRC LMB! It is an amazing place to start your own lab.
@mrclmb.bsky.social
Please get in touch if you have any questions.
www.nature.com/naturecareer...
We have an opening for a research support officer. Come and join us! Please share.
Rob Klose
Ana Tufegdzic Vidakovic
Time for a new pre-print! How do dendritic cells control pore formation in their own endocytic compartments?
Our work shows that the unique transmembrane anchor of perforin-2 does not protect DC membranes, but instead it enables antigen escape during cross-presentation
doi.org/10.64898/202...
How did life arise from simple chemical building blocks?
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
The ad is still open - if you are interested in structural biology of new RNA Pol II regulators, check out the postdoc position below 👇
It was great fun collaborating with Scott Berry's lab, as always! @scottbscience.bsky.social @cftbla.bsky.social
Wonderful to see this work online 🧪 🔬 🧫! How cells respond to changes in RNA Pol II abundance 👇
Lori Passmore
Video
Research Group Leader Tenure Track Starting Salary £67,979 to £76,868 per annum MRC Laboratory of Molecular Biology, Cambridge, UK The MRC Laborato...
Please spread the word: the Structural Studies Division @mrclmb.bsky.social is looking for a new tenure-track, independent group leader with an exciting plan in any area of Structural (Molecular & Cell) biology, in discovery biology and/or methods development. 🥳
mrc.tal.net/vx/mobile-0/...
Location: Cambridge. Vacancy: Research Group Leader Tenure Track - Structural Studies - LMB 2775. Closing Date: 16/03/2026, 23:55
We are looking for a postdoc to join us on the quest for understanding RNA Pol II destruction machines! If you are curious why more than 80% of Pol II are removed from genes, check out the post below:
www.nature.com/naturecareer...
Are you an enthusiastic and ambitious scientist looking for a challenging project?
Come and join @kellythd-nguyen.bsky.social’s group as a Research Support Officer and help decipher the molecular mechanisms of telomere maintenance!
Apply by 11 JAN
www.jobs.ac.uk/job/DPU715/r...
Postdoctoral Scientist Salary £42,694 per annum pro rata Fixed term for 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Applications are...
www.nature.com
What happens when you suddenly remove half of an essential enzyme from cells? 🤔
We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance.
Our lab's new preprint 👇
bit.ly/4pyPgax
Ana Tufegdzic Vidakovic
MRC Laboratory of Molecular Biology
Scott Berry
RNA polymerase II (Pol II) abundance and transcriptional output are coordinated across diverse conditions to maintain mRNA homeostasis. To determine whether Pol II acts as a limiting factor for transc...
